Voltage-Gated Potassium Channel Kv3.1b is Regulated by the Sodium Channel Beta3 Subunit
نویسندگان
چکیده
منابع مشابه
Voltage-gated ion channel accessory subunits: sodium, potassium, or both?
Commentary The voltage-gated potassium channel subunit Kv4.2 is a pore-forming alpha subunit of A-type potassium channels. Kv4.2, encoded by the KCND2 gene, is broadly expressed in the central nervous system and is predominantly localized on neuronal dendrites, with increased density on distal dendrites (1). A-type potassium channels are important regulators of neuronal excitability, modulating...
متن کاملThe batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate.
Batrachotoxin (BTX), from South American frogs of the genus Phyllobates, irreversibly activates voltage-gated sodium channels. Previous work demonstrated that a phenylalanine residue approximately halfway through pore-lining transmembrane segment IVS6 is a critical determinant of channel sensitivity to BTX. In this study, we introduced a series of mutations at this site in the Na(v)1.3 sodium c...
متن کاملCardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.
Na(v)1.5, the cardiac isoform of the voltage-gated Na+ channel, is critical to heart excitability and conduction. However, the mechanisms regulating its expression at the cell membrane are poorly understood. The Na(v)1.5 C-terminus contains a PY-motif (xPPxY) that is known to act as binding site for Nedd4/Nedd4-like ubiquitin-protein ligases. Because Nedd4-2 is well expressed in the heart, we i...
متن کاملA prokaryotic voltage-gated sodium channel.
The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. The sequence, especially in the pore region, is similar to that of voltage-gated calcium channels. The expressed cha...
متن کاملThe isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel
Domains in macromolecular complexes are often considered structurally and functionally conserved while energetically coupled to each other. In the modular voltage-gated ion channels the central ion-conducting pore is surrounded by four voltage sensing domains (VSDs). Here, the energetic coupling is mediated by interactions between the S4-S5 linker, covalently linking the domains, and the proxim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.1686